Sanctions have become nowadays one of the most seminal and used non-forceful instruments of international relations. Over the last decades, the United Nations Security Council has incredibly increased the resort to binding resolutions disposing of the application of sanctions against States alleged for having perpetrated a threat to or a breach of international peace and security. Nevertheless, the international community has continued to formulate doubts over their implementation, particularly due to the human rights concerns emerged following the humanitarian disaster occurred in Iraq after the establishment of the 661 Sanctions Regime. This has led the UN Security Council to initiate an evolutive process which resulted in the emergence of a new typology of such measures: targeted sanctions. Despite it is clear that through their application the UN has progressively lowered the probability of negatively impacting on the population of the targeted State, targeted sanctions have also ultimately generated new concerns over their application, particularly within the dimension of individual procedural rights.